In Looney Tunes Mayhem, 2 to 4 players sit in the directors chair as two teams of the wackiest Toons face off in this tag-team rumble. Only by using the best strategy and everything ACME has to offer can one team be the last one on screen when the smoke clears.

Players will move their Toons through iconic locations from the cartoons in the pursuit of Victory Points (VP), using their special skills to try to knock each other out and trying to avoid the other teams tricks and traps across the board.