The Sinister Six has had more than six members over the years, though they were always united in their hatred of Spider-Man. But when some of them succumb to the zombie outbreak, the remainder find themselves in the unenvious task of having to team up with Super Heroes to stop them.

The Marvel Zombies: A Zombicide Game Clash of the Sinister Six expansion brings players more game pieces and tiles to use in their games of Marvel Zombies. This expansion introduces Team vs Team mode. Players face off across the undead divide, looking to either save New York or devour it.